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Tramadol is a centrally acting pain medication that belongs to the group of weak opioids. The special property of this drug is its "dual mechanism of action": it stimulates opioid receptors and inhibits reuptake of serotonin and norepinephrine. Thanks to the above mechanism of action, tramadol can have an effect in cases where simple anti-inflammatory medications cannot alleviate the condition, which is why this drug can be used in many hard-to-treat cases. Having been discovered in Germany in the 1960s and put into practice in the 1970s, tramadol is today one of the most widely-used opioids in the world, mostly due to the lesser danger it poses compared to morphine.

Tramadol has an intermediate place in pain treatment. It is more potent than ibuprofen or diclofenac, but less potent (and also safer) than morphine or fentanyl. That is why tramadol is typically chosen when NSAID treatment doesn't work and switching to opioid painkillers will be an exaggeration. Tramadol is usually recommended in many guidelines as a step 2 drug in WHO analgesic ladder for moderate pain treatment.

Tramadol, after a surgical operation or a trauma injury, is very effective in the pain relief process that occurs during the period of recovery to enable patients to move and breathe well. In cases where the ordinary pain killers are not effective enough to relieve cancer pain, oncologists recommend this medication. In addition, for long term illnesses such as osteoarthritis and low back pain, it helps to relieve pain when other forms of medication have not been successful.