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Ambien or Zolpidem is one of the most researched and evidence-based medications used for the short-term treatment of insomnia and other sleep initiation disorders. Targeting gamma-aminobutyric acid receptors of the brain, it decreases excessive activity of neurons and thus facilitates the process of falling asleep for the patient. The precise regulation of the sleep-wake cycle along with its relatively fast onset of action make Ambien the drug of choice of many healthcare professionals and patients.

The mechanism of action of zolpidem is based on selective binding to GABA-A receptor subtypes responsible for sedative effect on the brain but not for muscle relaxant effect and anxiety reduction. As a result, Zolpidem does not cause any alterations of the structure of the sleep and allows for restoring normal sleep cycles, during which the body is recovering physically and mentally.

The clinical research has shown the effectiveness of Ambien in decreasing the sleep latency (time it takes to fall asleep) by the amount of 15-30 minutes after ingestion. Moreover, patients receiving Zolpidem also show increased total sleep time and decreased number of awakenings at night.